Noxious input to the spinal cord is known to produce central sensitization, which consists of allodynia , exaggeration of pain, and punctuate hyperalgesia , extreme sensitivity to pain. Two types of mechanical hyperalgesia can occur: 1) touch that is normally painless in the uninjured surroundings of a cut or tear can trigger painful sensations (touch-evoked hyperalgesia), and 2) a slightly painful pin prick stimulation is perceived as more painful around a focused area of inflammation (punctuate hyperalgesia). Touch-evoked hyperalgesia requires continuous firing of primary afferent nociceptors, and punctuate hyperalgesia does not require continuous firing which means it can persist for hours after a trauma and can be stronger than normally experienced. In addition, it was found that patients with neuropathic pain, histamine ionophoresis resulted in a sensation of burning pain rather than itch, which would be induced in normal healthy patients. This shows that there is spinal hypersensitivity to C-fiber input in chronic pain. 
The topic of my master’s thesis evolved not only from my own interest and fascination of jacquard weaving. A little bit of luck contributed to the final outcome of this study as well. At an early point of my study, I wanted to discuss the material and col-our design of woven textiles. I considered various ways on how to approach the subject from a fresh and meaningful point of view. In the beginning of the spring of 2014, I spent three months on an internship at the Italian weaving mill Lodetex. Lodetex is specialized in the production of jacquard fabrics for furnishing markets. I decided that doing my thesis in collaboration with Lodetex would be a viable continuum after working in the company as an intern. I discussed the matter with owner Luca Farhanghi and he agreed that a thesis collaboration would be interesting and beneficial for the both of us. He informed me about a few production lines that the company planned on developing. One of these lines related to clipped designs. To me, the development of clipped designs seemed like a fascinating and interesting topic to research. Since I had already designed two clipped designs during my internship, I realized that the weaving process of these fabrics required more advanced technical understanding in interwoven structure of cloth. Therefore, this project gave me a chance to improve my skills in artistic expression as well as develop my knowledge in designing, weaving and finishing of clipped cloths.
Injectable steroids are injected into muscle tissue, not into the veins. They are slowly released from the muscles into the rest of the body, and may be detectable for months after last use. Injectable steroids can be oil-based or water-based. Injectable anabolic steroids which are oil-based have longer half-life than water-based steroids. Both steroid types have much longer half-lives than oral anabolic steroids. And this is proving to be a drawback for injectables as they have high probability of being detected in drug screening since their clearance times tend to be longer than orals. Athletes resolve this problem by using injectable testosterone early in the cycle then switch to orals when approaching the end of the cycle and drug testing is imminent.