The stability-control button at the top of the M3’s four-button stack merits due deliberation. One tap disables traction control, handy for extracting the M3 from a snowbank. Pressing and holding the button for a few seconds engages the M Dynamic mode, where nearly all stability-control assistance is suspended. This eliminates understeer at the limit of adhesion. M Dynamic mode should be restricted to the racetrack, where neutral handling allows you to glide around sweepers with the tail hung wide in perfect synchronicity with the steering angle you’ve dialed in to the front wheels. Let your driving ability and insurance coverage be your guide.
The ThinPrep® PapTest TM (Cytyc Corp., Marlborough, MA), and SurePath (TriPath Imaging Inc., Burlington, NC) are automated liquid-based thin layer slide preparation techniques. With the ThinPrep System, a conventional Pap smear is not performed. Using a spatula and a brush or a cervical broom, the cervical area is sampled and the devices are rinsed in a fixative solution. The slide is then automatically made in the laboratory, which decreases the possibility of air-drying artifacts. It is then stained and read by a technician or a cytopathologist. SurePath (formerly known as AutoCyte PREP) is another liquid-based thin-layer sample preparation system that uses centrifugation to separate cells from obscuring material, and automatically prepares and stains cytology slides.
The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system.