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What’s in your medicine cabinet? Medications are to blame for a quarter of all cases of man boobs, according to research published in the New England Journal of Medicine. More than two-dozen prescription drugs have estrogen-like properties, raise levels of estrogen directly, or include androgen hormones that can be converted into estrogen, says Galiano. These include commonly prescribed medications such as amphetamines, antidepressants, blood pressure drugs, and antibiotics. But chances are your doctor hasn’t told you about their super un-sexy side effect. “It is so rare that most doctors don’t worry about it,” Galiano says. “Ask your doctor if your current medications can cause gynecomastia, and if you are on any of them, tell your doctor if you begin to see any change before it gets out of control.”