The safety concerns of consuming products with saccharin remain even with the removal of the warning. According to a report written in 1997 by the Center for the Science in Public Interest (CSPI) in response to the National Toxicology Program (NTP) removing saccharin from the list of potential carcinogens, "It would be highly imprudent for the NTP to delist saccharin. Doing so would give the public a false sense of security, remove any incentive for further testing, and result in greater exposure to this probable carcinogen in tens of millions of people, including children (indeed, fetuses). If saccharin is even a weak carcinogen, this unnecessary additive would pose an intolerable risk to the public. Thus, we urge the NTP on the basis of currently available data to conclude that saccharin is 'reasonably anticipated to be a human carcinogen' because there is 'sufficient' evidence of carcinogenicity in animals (multiple sites in rats and mice) and 'limited' or 'sufficient' evidence of carcinogenicity in humans ( bladder cancer ) and not to delist saccharin, at least until a great deal of further research is conducted."
Since the 1990's, many epidemiological and toxicological studies have addressed the effect of current ambient levels of air pollution on mortality. KNOWLEDGE: Several epidemiological studies found a short-term association between all cause, cardiovascular and respiratory mortality, and various air pollutants. These results were notably established in French, European and American multicentre studies as well as in meta-analysis. Furthermore, some studies have identified populations that are more vulnerable to the effects of air pollutants. Children, the elderly, patients with chronic diseases and people with lower socioeconomic status have been found to be more susceptible to air pollution.
Most drugs of abuse are addictive. Addiction is a chronic, relapsing disease characterized by compulsive drug seeking and use despite negative consequences and by long-lasting changes in the brain. People who are addicted have strong cravings for the drug, making it difficult to stop using. Most drugs alter a person’s thinking and judgment, which can increase the risk of injury or death from drugged driving or infectious diseases (., HIV/AIDS, hepatitis) from unsafe sexual practices or needle sharing. Drug use during pregnancy can lead to neonatal abstinence syndrome, a condition in which a baby can suffer from dependence and withdrawal symptoms after birth. Pregnancy-related issues are listed in the chart below for drugs where there is enough scientific evidence to connect the drug use to negative effects. However, most drugs could potentially harm an unborn baby.