I had a gout attack about 7 months ago. I’m a vegan who gets lots of fiber. Soon after the attack my uric acid level was determined to be , which is high normal (but one can get gout attacks with normal levels). I started drinking 4 cups of decafe coffee and 2 TBL of tart cherry concentrate, eating less fruit that is high in fructose (. I eat no dried fruit and only unripe bananas), and taking a 500 mg vitamin C supplement each day, since I had read that each of these can lower uric acid, although individually the effect might not be “clinically significant”. My uric acid level is now , which is in the range that doctors are aiming for when prescribing gout medicine. Unfortunately I do not know how much each component of my dietary changes has lowered my results but assume it is a cumulative effect.
In an attack of several days' duration prior to starting therapy, a longer course of treatment may be necessary. In such patients, added interventions to prevent NSAID gastropathy (eg, use of a proton pump inhibitor) may be of benefit, particularly in patients at increased risk due to advanced age or to a prior history of ulcer disease or gastrointestinal bleeding. (See "NSAIDs (including aspirin): Primary prevention of gastroduodenal toxicity" and "NSAIDs (including aspirin): Secondary prevention of gastroduodenal toxicity" .)
Inhibition of xanthine oxidase by some Chinese
medicinal plants used to treat gout.
J Ethnopharmacol. 2000.
The enzyme xanthine oxidase catalyses the oxidation of hypoxanthine to xanthine and then to uric acid, which plays a crucial role in gout. A total of 122 traditional Chinese medicinal plants have been evaluated for the enzyme inhibitory activity. The most active was the methanol extract of the twig of Cinnamomum cassia, which was followed immediately by those of the flower of Chrysanthemum indicum and the leaves of Lycopus europaeus. Among the water extracts, the strongest inhibition of the enzyme was observed with that of the rhizome of Polygonum cuspidatum. The study demonstrated that the effects for these medicinal plants used for the gout treatment were based, at least in part, on the xanthine oxidase inhibitory action.