Estrogenic steroids definition

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In normal tissue, DIM (300nM) can activate the ATM genetic repair pathway in response to irradiation damage in a manner dependent on BRCA1 (one of its targets [36] ) without increasing survival of breast cancer cells (MDA-MB-231 [36] ); there are known alterations in this pathway in some breast cancers where BRCA1 is reduced while ATM itself seems to be hyperactive, and oral supplementation of 300mg DIM has been noted to increase BRCA1 mRNA levels after 4-6 weeks supplementation (measured in white blood cells) in women who had a low activity mutation. [39]

Estrogenic steroids definition

estrogenic steroids definition

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