477 mg of (1,2-ethanediyl) cyclic acetal of 11β-[4-(dimethylamino)-phenyl]-19-nor-17α-Δ 9 -pregnen-20-yn-5α,17β-diol-3-one were dissolved in 5 ml of hexamethylphosphorotriamide and 2,6 ml of tributyltin hydride were added under an inert atmosphere. The mixture was heated to 70° C. for 25 hours, then cooled, diluted with water and extracted with ethyl acetate. The organic phase was washed with water, dried and concentrated to dryness. The residue was chromatographed on silica and eluted with a petroleum-ether (: 40°-70° C.) /ether mixture (6-4) to obtain 214 g of isomer (E), 135 mg of the mixture of isomers (E) and (Z) and 346 mg of the expected isomer (Z).
As alluded to above, one very important thing to acknowledge when using AAS (whether taking one hormone, stacking or cycling) is the risk of harmful side effects. Within a steroid cycle, the users will often stack other non-anabolic hormones into their program to maximize specific cycle objectives for example: the addition of drugs like Clenbuterol and/or Cytomel /T3 augment cutting/definition cycles; others called aromatase inhibitors (estrogen reducing drugs) like Letrozole . Letro and Anastrozole Arimidex are often included to inhibit the conversion of excess testosterone to negatively cycle impacting estrogen and; incorporating post-cycle therapy (PCT) drugs such as the synthetic estrogens Tamoxifen . Nolvadex , or Clomiphene Citrate . Clomid (which act as anti-estrogens in the male body), can be used alone, together, or in conjunction with those like Mesterolone . Proviron and Human Chorionic Gonadotropin ( HCG ) during PCT to bridge the gap between the end of a steroid cycle (synthetic testosterone usage) and the restoration of the bodys natural testosterone production. These drugs too must be researched, and controlled in similar fashion to AAS. Thus, steroid cycles can be as simple or complex as the users individualized goals, cycle histories and levels of understanding. Below are three samples of AAS stacked cycles of varying complexity along with a beginning PCT sample, and an explanation of goal intention & rationale for the selected compounds, dosages & durations. These illustrations and commentaries will provide a better understanding of what stacking and cycling are along with the many nuances they require.
Trenbolone is often touted as an anabolic steroid that has ‘harsh’ side effects and tends to frighten many individuals who are considering the use of this compound. First and foremost, it should be established that because Tren does not aromatize into Estrogen at any dosage, there is no risk for encountering Estrogenic side effects . The Trenbolone side effects of particular concern are its androgenic side effects, and other side effects that are not usually seen with any other anabolic steroids (such as insomnia, excessive sweating, etc.).